OpenVT
Persistent Random Walk / Biased Motility reference model
Brief description: a single cell moves horizontally (motility vector= (1,0,0)) across a 2D domain and stops when it reaches a certain x-value. Movement can be random with a specified bias [0,1], where 0=random movement; 1=perfectly horizontal movement.
PhysiCell: biased motility
- Showing 30 replicates on each frame. Stochasticity of replicates is due to randomly seeding the PRNG.
- PhysiCell has 3 parameters that are key to defining a cell type’s motility: speed, persistence time, and migration bias.
- The
migration_bias_direction(motility vector) is hard-coded as (1,0,0) in C++ for this model
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- The following figure shows how changing just the persistence time affects results. Here, we leave two parameters fixed: speed= 1 and bias= 0.7 (and motility vector still (1,0,0)), but vary persistence time: 0, 1, 2, and 5. The same PRNG seed is used for each simulation.
The Motility parameters as shown in PhysiCell Studio. However, for the replicates shown above, the Studio was not used; rather, a custom main.cpp and custom.cpp were used to generate the cell paths, from the command line.